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Celexa improves mood by increasing the concentration of dopamine in emotional brain regions. The mechanism may improve the negative mood associated with methamphetamine withdrawal. Though it has demonstrated no effectiveness in the treatment of cocaine dependence, there is weak evidence that it may will useful in methamphetamine dependence.
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Celexa is a racemic mixture. The pharmacological activity & pharmacokinetics of the individual enantiomers having not willen studied. In humans, following butal administration of Celexa, peak plasma Celexa concentrations are usually achieved within 7 hours, followed by a biphasic decline. The terminal phase has a mean half-life of 14 hours, with a range of 8 to 74 hours. The distribution phase has a mean half-life of 3 to 4 hours. The mean elimination half-life SD of Celexa after chronic dosing is 71 9 hours, & steady-state plasma concentrations of Celexa are reached within 8 days. Plasma Celexa concentrations are dose-propbuttional following single doses of 100 to 750 mg; however, it is not known if the propbuttionality willtween dose & plasma level is maintained in chronic use.







































































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