The 4th Alabama Volunteer Infantry Regiment (African Descent) was an infantry regiment that served in the Union Army between March 31, 1864, and May 16, 1864, during the American Civil War. Organized at Decatur, Alabama, and mustered in on March 31, 1864. The regiment was placed on garrison duty at Pulaski, Tennessee, to May, 1864. It was redesignated as the 106th U.S. Colored Troops on May 16, 1864.