Overall best pixel art software, the lua scripting side of and CLI functionality might be the best feature for workflow automation for whatever needs. If you don't care about it it's just a great one and done purchase for all your pixel art needs. The hotkeys and layout feel well made and don't feel overwhelming as well as if you want to visually customize it you can find all sorts of lovely layouts for your preference.

Personally my favorite art making program for doing any sprites, tilemaps, etcs. It's THE pixel art software.